NMDAreceptor相关论文
Objective N-methyl-D-aspartate(NMDA)receptors play important role in neurological diseases,including epilepsy....
The protective effect of NMDA receptor inhibitors on nigral iron accumulation in 6-OHDA-induced Park
Parkinsons disease(PD)is a neurodegenerative disease,which is mainly occurred in elderly person....
ɑ-Synuclein-induced internalization of NMDA receptors in hippocampal neurons is associated with redu
Abnormal α-synuclein(α-syn)expression and aggregation have been implicated in the pathogenesis of Parkinsons disease(P......
Protopanaxadiol ginsenoside-Rd protects against NMDA receptor-mediated neuronal injury by inhibiting
...
Protein kinase C promotes NMDA receptor trafficking by indirectly triggering CaMKⅡ autophosphorylati
Regulation of neuronal NMDA receptor is critical in synaptic transmission and plasticity.Protein kinase C (PKC) promotes......
Ischemia elicits rapid release of various amino acids including glycine, which is the co-agonist of NMDA receptor (NMDAR......
Acute effects of 17β-estradiol on excitatory synaptic transmission and long-term potentiation in rat
Discussions about how estrogen modulates pain sensitivity have largely focused on genomic actions via nuclear receptors,......
Rapid effect of estrogen on glutamate related synaptic transmission and plasticity,in the anterior c
Classically, estrogen has multiple actions in the brain via genomic mechanisms which generally take several hours.The pr......
Changes of NMDA receptor expression in rat hippocampal formation after establishment of spatial memo
A number of studies during the past decades have suggested a critical role of glutamatergic N-methyl-D-aspartate (NMDA) ......
Objective In our previous study,we had proposed that in the upper stream of the known ciliary neurotrophic factor (CNTF)......
Objective: Recently,we have demonstrated that glutamate,the most abundant excitatory neurotransmitter in the central ner......
Timosaponin from Chinese herb Rhizoma anemarrhenae has been indicated to have essential effect in both clinical depressi......
Oscillatory firing is an important process in neural system for presenting, integrating and synchronizing neuronal signa......
Sigma receptor 1 is involved in modulation of NMDA receptor-mediated neurotransmission in rat retina
Sigma receptors (σRs), which are classified into three subtypes (σR1, σR2, σR3), are widely distributed in the centr......
Switching of N-methyl-D-aspartate (NMDA) receptor-favorite intracellular signal pathways from ERK1/2
Excitotoxicity mediated by overactivation of N-methyl-D-aspartate receptors (NMDARs) has been implicated in a variety of......
Neuronal NR2B-containing NMDA receptor mediates astrocytic c-Jun N-terminal kinase activation in a r
Objective The N-methyl-D-aspartate receptor (NMDAR) in the superficial dorsal horn is implicated as a major contributor ......
Effects of glutamic acid on spontaneous discharges of arcuate nucleus in hypothalamic slice from nor
To study the influence of glutamic acid (Glu) on the electric activities of arcuate nucleus (ARC) neurons in the normal ......
The inferior colliculus(IC)is a major synaptic integration center in the central auditory pathway....
Objective The hippocampal parallel excitatory pathways referred to as the trisynaptic pathway (entorhinal cortex → dent......
Objective Schizophrenia patients always have significant attenuated mismatch negativity (MMN) response, which reveals a ......
Background: Intrauterine hypoxia is one of the important causes of lung dysplasia in fetal, while the mechanism has not ......
NMDARs and ASIC1a both exist in central synapses and mediate important physiological and pathological conditions,but the......
Rapid and long-lasting antidepressant effects of Yueju are associated with its instant and lasting d
Accumulating evidence indicated that N-methyl-D-aspartate(NMDA)receptors are involved in the pathophysiology of depressi......
Glutamate stimulation induces a two-phase cofilin rod formation mediated by both NMDA and non-NMDA r
Objective Cofilin is the major actin-depolymerizing factor in the CNS for regulation of actin dynamics.Neurodegenerative......
Effect of chronic methylphenidate exposure on NMDA receptor phosphorylation and expression in the me
Methylphenidate is widely used for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD), but the molecular m......
Inhibitor of MAPK/ERK kinase but not NMDA receptor antagonist blocks the survival-promoting effect o
There is growing evidence demonstrating that hippocampus-dependent learning can rescue the newly generated neurons from ......
A three amino acid tail following the TM4 region of NR2 subunits is sufficient to overcome ER retent
The cytoplasmic C-terminal domains of NR2 subunits have been proposed to modulate the assembly and trafficking of NMDA r......
Glycine binding sites of presynaptic NR2B-containing NMDA autoreceptors may tonically regulate gluta
Johnson and Ascher first demonstrated that,in the vertebrate central nervous system (CNS),exogenously applied glycine po......
NMDA receptor-dependent synaptic acitivity in dorsal motor nucleus of vagus mediates the upregulatio
Previous studies have demonstrated the efficacy of electroacupuncture at ST36 for patients with gastrointestinal motilit......
Spiders are traditional medicine used for the treatment of chronic pain,but the molecular mechanism involved is not clea......
Glutamate-induced down-regulation of of Tuberous Sclerosis Complex Proteins 2 (TSC2) in the Cortical
mTOR signaling is a major molecular pathway that controls activity-dependent protein synthesis in dendrites of hippocamp......
Hydroxysafflor yellow A protects neurons from excitotoxic death through inhibition of NMDA receptors
Excessive glutamate release causes over-activation of NMDARs,leading to excitatory neuronal damage in cerebral ischemia.......
N-methyl-D-aspartate receptors(Tsien et al.)are crucial for excitatory synaptic transmission and plasticity,learning and......
Given the NMDA receptor(NMDAR)plays a central role in various brain functions,the trafficking of NMDAR in response to sy......
Memantine attenuates reinstatement of heroin seeking induced by heroin or cues in an animal model of
OBJECTIVE To study the effects of acute treatment with memantine on the heroin seeking behavior.MEHTODS Rats were self-a......
Effects of NR2A overexpression on prefrontal synaptic plasticity and prefrontal cortex-related memor
Objective N-methyl-D-aspartate receptors (NMDARs) play an important role in learning and memory.NR2A and NR2B subunits a......
N-methyl-D-aspartate (NMDA) receptors are ionotropic glutamate receptor subtype in the central nervous system (CNS), whi......
The pain experience includes a sensory-discriminative and an affective-emotional component.The anterior cingulate cortex......
Surface expression of hippocampal NMDA GluN2B receptors regulated by fear conditioning determines it
The number and subtype composition of N-methyl-d-aspartate receptors(NMDARs)at synapses determines their functional prop......
Protein Phosphatase 1 Inhibitor-2 Signaling in Synaptic Plasticity and Memory Formation Inhibitor-2:
Protein phosphatase-1(PP1)plays a critical role in synaptic plasticity and memory formation.PP1 activity is required for......
Irritable bowel syndrome (IBS) is charactered with visceral hypersensitivity,which is often exacerbated by stress.We pre......
Protein Kinase C Promotes NMDA Receptor Trafficking by Indirectly Triggering CaMKII Autophosphorylat
Regulation of neuronal NMDA receptor is critical in synaptic transmission and plasticity.Protein kinase C (PKC) promotes......
Propofol local injection relieve neuropathic pain through suppressing NMDA-2B receptors of sciatic n
...
The aryl hydrocarbon receptor (AhR) is a ligand-activated basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription f......
Glutamate (Glu) is a major excitatory neurotransmitter in central nervous system, but high extracellular concentration o......
Role of the NR2B-containing NMDA receptor-ERK pathway in nucleus accumbeus shell in morphine-associa
Learned associations between the rewarding effect of addictive drugs and drug-paired contexts resist extinction and cont......
N-methyl-D-aspartate receptors (NMDAR) are gluta mate gated ion channels mediating the vast majority of excitatory neuro......
